Pharmacological effects and metabolism of extracellular ATP.
نویسندگان
چکیده
منابع مشابه
[Extracellular ATP: effects, sources and fate].
The change of extracellular adenosine triphosphate (ATP) concentration affects many important physiological functions significantly. As a transmitter, ATP acts on neuro-effector junction directly and/or modulates the release of other neurotransmitters. By acting on the various P2-purinoceptors or ionic channels on the membrane, ATP also has some striking effects on cell activities. This review ...
متن کاملMethylene ATP analogs as modulators of extracellular ATP metabolism and accumulation.
1 Transient accumulation of extracellular ATP reflects both release of ATP from intracellular stores and altered rates of ATP metabolism by ecto-enzymes. Ecto-nucleoside triphosphate diphosphohydrolases (eNTPDases) and ecto-nucleotide pyrophosphatases (eNPPs) degrade ATP, while ecto-nucleotide diphosphokinases (eNDPKs) synthesize ATP from ambient ADP. 2 Although the methylene ATP analogs betaga...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1991
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.98.3_235